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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers
|
|---|---|
| Published in |
Frontiers in Psychiatry, January 2013
|
| DOI | 10.3389/fpsyt.2013.00114 |
| Pubmed ID | |
| Authors |
Jason D. Robinson, Francesco Versace, Cho Y. Lam, Jennifer A. Minnix, Jeffrey M. Engelmann, Yong Cui, Maher Karam-Hage, Sanjay S. Shete, Gail E. Tomlinson, Tina T.-L. Chen, David W. Wetter, Charles E. Green, Paul M. Cinciripini |
| Abstract |
A compromised brain reward system has been postulated as a key feature of drug dependence. We examined whether several polymorphisms of genes found to regulate nicotinic acetylcholine receptor (nAChR) and dopamine expression were related to an intrinsic reward sensitivity (IRS) deficit we previously identified among a subgroup of smokers using event-related potentials (ERPs). We examined genetic polymorphisms within the CHRNA5-A3-B4 gene cluster (CHRNA3 rs578776, CHRNA5 rs16969968, LOC123688 rs8034191, and CHRNA3 rs1051730), the ANKK1 gene (rs1800497), and the D2 dopamine receptor gene (DRD2 rs1079597, DRD2 rs1799732) from 104 smokers of European ancestry in a smoking cessation trial. Prior to treatment, we recorded ERPs evoked by emotional (both pleasant and unpleasant), neutral, and cigarette-related pictures. Smokers were assigned to two groups (IRS+/IRS-) based on the amplitude of the late positive potential (LPP) component to the pictures, a neural marker of motivational salience. Smokers (n = 42) with blunted brain responses to intrinsically rewarding (pleasant) pictures and enhanced responses to cigarette pictures were assigned to the IRS- group, while smokers (n = 62) with the opposite pattern of LPP responding were assigned to the IRS+ group. Carriers of the protective minor T allele (T/T, C/T) of the CHRNA3 rs578776 were less likely to be members of the IRS- group than those homozygous for the at-risk C allele (C/C). The CHRNA3 rs578776 polymorphism did not differ on questionnaires of nicotine dependence, depressed mood, or trait affective disposition and did not predict abstinence at 6 months after the quit date. These results suggest that polymorphisms of genes influencing nAChR expression are related to an endophenotype of reward sensitivity in smokers. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 14% |
| Other | 5 | 9% |
| Student > Doctoral Student | 5 | 9% |
| Researcher | 5 | 9% |
| Student > Ph. D. Student | 5 | 9% |
| Other | 11 | 20% |
| Unknown | 17 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 20% |
| Medicine and Dentistry | 9 | 16% |
| Neuroscience | 6 | 11% |
| Agricultural and Biological Sciences | 4 | 7% |
| Nursing and Health Professions | 1 | 2% |
| Other | 6 | 11% |
| Unknown | 19 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2013.
All research outputs
#20,203,867
of 22,723,682 outputs
Outputs from Frontiers in Psychiatry
#7,624
of 9,841 outputs
Outputs of similar age
#248,790
of 280,763 outputs
Outputs of similar age from Frontiers in Psychiatry
#163
of 185 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,841 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 185 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.