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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential Pharmacological Effects on Brain Reactivity and Plasticity in Alzheimer’s Disease
|
|---|---|
| Published in |
Frontiers in Psychiatry, January 2013
|
| DOI | 10.3389/fpsyt.2013.00124 |
| Pubmed ID | |
| Authors |
Anna-Katharine Brem, Natasha J. Atkinson, Erica E. Seligson, Alvaro Pascual-Leone |
| Abstract |
Acetylcholinesterase inhibitors (AChEIs) are the most commonly prescribed monotherapeutic medications for Alzheimer's disease (AD). However, their underlying neurophysiological effects remain largely unknown. We investigated the effects of monotherapy (AChEI) and combination therapy (AChEI and memantine) on brain reactivity and plasticity. Patients treated with monotherapy (AChEI) (N = 7) were compared to patients receiving combination therapy (COM) (N = 9) and a group of age-matched, healthy controls (HCs) (N = 13). Cortical reactivity and plasticity of the motor cortex were examined using transcranial magnetic stimulation. Cognitive functions were assessed with the cognitive subscale of the Alzheimer Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), activities of daily living (ADLs) with the ADCS-ADL. In addition we assessed the degree of brain atrophy by measuring brain-scalp distances in seven different brain areas. Patient groups differed in resting motor threshold and brain atrophy, with COM showing a lower motor threshold but less atrophy than AChEI. COM showed similar plasticity effects as the HC group, while plasticity was reduced in AChEI. Long-interval intracortical inhibition (LICI) was impaired in both patient groups when compared to HC. ADAS-Cog scores were positively correlated with LICI measures and with brain atrophy, specifically in the left inferior parietal cortex. AD patients treated with mono- or combination-therapy show distinct neurophysiological patterns. Further studies should investigate whether these measures might serve as biomarkers of treatment response and whether they could guide other therapeutic interventions. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 2% |
| Unknown | 53 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 17% |
| Student > Master | 8 | 15% |
| Student > Bachelor | 8 | 15% |
| Researcher | 6 | 11% |
| Other | 4 | 7% |
| Other | 10 | 19% |
| Unknown | 9 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 20% |
| Agricultural and Biological Sciences | 10 | 19% |
| Psychology | 10 | 19% |
| Medicine and Dentistry | 5 | 9% |
| Social Sciences | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2013.
All research outputs
#18,349,805
of 22,725,280 outputs
Outputs from Frontiers in Psychiatry
#6,794
of 9,844 outputs
Outputs of similar age
#218,065
of 280,762 outputs
Outputs of similar age from Frontiers in Psychiatry
#154
of 185 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,844 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,762 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 185 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.