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Neurological Soft Signs in the Clinical Course of Schizophrenia: Results of a Meta-Analysis

Overview of attention for article published in Frontiers in Psychiatry, December 2014
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Title
Neurological Soft Signs in the Clinical Course of Schizophrenia: Results of a Meta-Analysis
Published in
Frontiers in Psychiatry, December 2014
DOI 10.3389/fpsyt.2014.00185
Pubmed ID
Authors

Silke Bachmann, Christina Degen, Franz Josef Geider, Johannes Schröder

Abstract

Neurological soft signs (NSS) comprise subtle deficits in sensory integration, motor coordination, and sequencing of complex motor acts, which are typically observed in the majority of schizophrenia patients, including chronic cases and neuroleptic-naïve first-episode patients. However, recent studies clearly demonstrate that NSS are not a static feature of schizophrenia but vary in the clinical course of the disorder. This effect was investigated in a meta-analysis based on 17 longitudinal studies published between 1992 and 2012. Studies included between 10 and 93 patients with schizophrenia spectrum disorders (total number 787) with follow-up periods between 2 and 208 weeks. Beside the Neurological Examination Scale, the Cambridge Neurological Inventory and the Heidelberg NSS Scale were used to assess NSS. All but three studies found NSS to decrease in parallel with remission of psychopathological symptoms. This effect was more pronounced in patients with a remitting compared to a non-remitting, chronic course (Cohen's d 0.81 vs. 0.15) and was significantly correlated with length of the follow-up period (r = -0.64) but not with age (r = 0.28). NSS scores did not decrease to the level typically observed in healthy controls. From a clinical perspective, NSS may therefore be used to identify subjects at risk to develop schizophrenia and to monitor disease progression.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 108 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 15%
Student > Bachelor 13 12%
Student > Postgraduate 12 11%
Student > Ph. D. Student 12 11%
Student > Doctoral Student 11 10%
Other 23 21%
Unknown 22 20%
Readers by discipline Count As %
Medicine and Dentistry 34 31%
Psychology 26 24%
Neuroscience 7 6%
Nursing and Health Professions 3 3%
Social Sciences 3 3%
Other 5 5%
Unknown 31 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2016.
All research outputs
#16,237,186
of 25,654,806 outputs
Outputs from Frontiers in Psychiatry
#5,828
of 12,873 outputs
Outputs of similar age
#200,588
of 360,729 outputs
Outputs of similar age from Frontiers in Psychiatry
#37
of 54 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,873 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,729 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.