The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy
|
|---|---|
| Published in |
Frontiers in Psychiatry, December 2015
|
| DOI | 10.3389/fpsyt.2015.00172 |
| Pubmed ID | |
| Authors |
Charles F. Zorumski, Peter Nagele, Steven Mennerick, Charles R. Conway |
| Abstract |
Major depressive disorder (MDD) remains a huge personal and societal encumbrance. Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression (TMRD), which afflicts 15-30% of MDD patients. There has been recent interest in N-methyl-d-aspartate receptors (NMDARs) as targets for treatment of MDD and perhaps TMRD. To date, most pre-clinical and clinical studies have focused on ketamine, although psychotomimetic and other side effects may limit ketamine's utility. These considerations prompted a recent promising pilot clinical trial of nitrous oxide, an NMDAR antagonist that acts through a mechanism distinct from that of ketamine, in patients with severe TRMD. In this paper, we review the clinical picture of TRMD as a subtype of MDD, the evolution of ketamine as a fast-acting antidepressant, and clinical and basic science studies supporting the possible use of nitrous oxide as a rapid antidepressant. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 24% |
| United Kingdom | 3 | 14% |
| Canada | 1 | 5% |
| Netherlands | 1 | 5% |
| Unknown | 11 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 76% |
| Scientists | 4 | 19% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 142 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 13% |
| Student > Master | 17 | 12% |
| Student > Ph. D. Student | 16 | 11% |
| Researcher | 13 | 9% |
| Student > Doctoral Student | 11 | 8% |
| Other | 30 | 21% |
| Unknown | 38 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 19% |
| Neuroscience | 19 | 13% |
| Psychology | 16 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 8% |
| Agricultural and Biological Sciences | 9 | 6% |
| Other | 19 | 13% |
| Unknown | 42 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2023.
All research outputs
#1,717,695
of 26,485,427 outputs
Outputs from Frontiers in Psychiatry
#1,054
of 13,207 outputs
Outputs of similar age
#27,152
of 398,933 outputs
Outputs of similar age from Frontiers in Psychiatry
#5
of 41 outputs
Altmetric has tracked 26,485,427 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,207 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 398,933 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.