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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer
|
|---|---|
| Published in |
Frontiers in Psychiatry, February 2018
|
| DOI | 10.3389/fpsyt.2018.00014 |
| Pubmed ID | |
| Authors |
Gerson D. Guercio, Rogerio Panizzutti |
| Abstract |
After 25 years of its discovery in the rat brain, d-serine is a recognized modulator of synaptic plasticity and cognitive processes through its actions on the NMDA-glutamate receptor. Importantly, cognitive impairment is a core feature of conditions, such as schizophrenia, Alzheimer's disease, depression, and aging, and is associated to disturbances in NMDA-glutamate receptors. The d-serine pathway has been associated with cognitive deficits and these conditions, and, for this reason, d-serine signaling is subject of intense research to probe its role in aiding diagnosis and therapy. Nevertheless, this has not resulted in new therapies being incorporated into clinical practice. Therefore, in this review we will address many questions that need to be solved by future studies, regarding d-serine pharmacokinetics, possible side effects, other strategies to modulate its levels, and combination with other therapies to increase its efficacy. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 6 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 18% |
| Researcher | 12 | 12% |
| Student > Master | 11 | 11% |
| Student > Ph. D. Student | 9 | 9% |
| Professor | 3 | 3% |
| Other | 10 | 10% |
| Unknown | 38 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 17% |
| Medicine and Dentistry | 10 | 10% |
| Agricultural and Biological Sciences | 8 | 8% |
| Psychology | 6 | 6% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 39 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2019.
All research outputs
#7,277,322
of 26,574,355 outputs
Outputs from Frontiers in Psychiatry
#3,491
of 13,237 outputs
Outputs of similar age
#132,097
of 452,589 outputs
Outputs of similar age from Frontiers in Psychiatry
#66
of 124 outputs
Altmetric has tracked 26,574,355 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 13,237 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.