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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls
|
|---|---|
| Published in |
Frontiers in Psychiatry, May 2018
|
| DOI | 10.3389/fpsyt.2018.00185 |
| Pubmed ID | |
| Authors |
Ana C. de Menezes Galvão, Raíssa N. de Almeida, Erick A. dos Santos Silva, Fúlvio A. M. Freire, Fernanda Palhano-Fontes, Heloisa Onias, Emerson Arcoverde, João P. Maia-de-Oliveira, Dráulio B. de Araújo, Bruno Lobão-Soares, Nicole L. Galvão-Coelho |
| Abstract |
Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C). Subjects received a single dose of ayahuasca or placebo (dosing session), and both plasma and awakening salivary cortisol response were measured at baseline (before dosing session) and 48 h after the dosing session. Baseline assessment (D0) showed blunted awakening salivary cortisol response and hypocortisolemia in patients, with respect to healthy controls. Salivary cortisol was also measured during dosing session, and we observed higher increases for both C and MD that ingested ayahuasca than placebo. After 48 h from the dosing session with ayahuasca, patients' awakening salivary cortisol response is similar to the ones detected in controls. No significant changes in plasma cortisol levels were observed 48 h after the sessions. Therefore, these findings point to new evidence on the modulation of salivary cortisol levels as a result of an ayahuasca session, both in healthy and depressive volunteers. Considering that cortisol acts in regulation of distinct physiological pathways, emotional and cognitive processes, it is assumed to be critically involved to the etiology of depression and its regulation seems to be important for the treatment and remission of major depression, ayahuasca use as antidepressant should be further investigated. Moreover, this study highlights the importance of psychedelics in the treatment of human mental disorders. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 14% |
| Canada | 2 | 9% |
| Bermuda | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 15 | 68% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 82% |
| Practitioners (doctors, other healthcare professionals) | 2 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 230 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 230 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 37 | 16% |
| Student > Master | 25 | 11% |
| Researcher | 19 | 8% |
| Student > Ph. D. Student | 14 | 6% |
| Student > Doctoral Student | 14 | 6% |
| Other | 37 | 16% |
| Unknown | 84 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 31 | 13% |
| Medicine and Dentistry | 30 | 13% |
| Neuroscience | 22 | 10% |
| Agricultural and Biological Sciences | 20 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Other | 28 | 12% |
| Unknown | 90 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2023.
All research outputs
#990,884
of 26,493,550 outputs
Outputs from Frontiers in Psychiatry
#604
of 13,209 outputs
Outputs of similar age
#20,703
of 345,581 outputs
Outputs of similar age from Frontiers in Psychiatry
#17
of 173 outputs
Altmetric has tracked 26,493,550 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,209 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,581 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 173 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.