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Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis

Overview of attention for article published in Frontiers in Psychiatry, July 2018
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Title
Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis
Published in
Frontiers in Psychiatry, July 2018
DOI 10.3389/fpsyt.2018.00286
Pubmed ID
Authors

Taekwan Kim, Kwang-Hyuk Lee, Hyerim Oh, Tae Young Lee, Kang Ik K. Cho, Junhee Lee, Jun Soo Kwon

Abstract

Introduction: The fundamental role of the cerebellum in higher cognitive processing has recently been highlighted. However, inconsistent findings exist in schizophrenia with respect to the exact nature of cerebellar structural abnormalities and their associations with cognitive and clinical features. Materials and Methods: We undertook a detailed investigation of cerebellar lobular volumes in 40 patients with first-episode psychosis (FEP) and 40 healthy controls (HCs) using the spatially unbiased atlas template of the cerebellum (SUIT). We examined the functional significance of cerebellar structural abnormalities in relation to cognitive and clinical outcomes in patients. Results: We found that left cerebellar lobules VI and X volumes were lower in FEP patients, compared to HCs. Smaller left lobules VI and X volumes were associated with fewer number of categories completed on the Wisconsin Card Sorting Test (WCST) in patients. In addition, smaller left lobule X volume was related to performance delay on the Trail Making Test (TMT) Part B in patients. Conclusion: Our results demonstrate that cerebellar structural abnormalities are present at the early stage of schizophrenia. We suggest functional associations of cerebellar structural changes with non-verbal executive dysfunctions in FEP.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 23%
Student > Ph. D. Student 5 13%
Student > Bachelor 3 8%
Student > Master 3 8%
Professor > Associate Professor 2 5%
Other 5 13%
Unknown 13 33%
Readers by discipline Count As %
Medicine and Dentistry 6 15%
Psychology 6 15%
Neuroscience 5 13%
Computer Science 1 3%
Nursing and Health Professions 1 3%
Other 4 10%
Unknown 17 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#18,639,173
of 23,090,520 outputs
Outputs from Frontiers in Psychiatry
#6,993
of 10,211 outputs
Outputs of similar age
#253,174
of 327,894 outputs
Outputs of similar age from Frontiers in Psychiatry
#153
of 174 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,211 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 174 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.