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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Full-Profile Pharmacokinetic Study of High Dose Baclofen in Subjects With Alcohol Use Disorder
|
|---|---|
| Published in |
Frontiers in Psychiatry, August 2018
|
| DOI | 10.3389/fpsyt.2018.00385 |
| Pubmed ID | |
| Authors |
Nicolas Simon, Romain Moirand, Maurice Dematteis, Régis Bordet, Dominique Deplanque, Benjamin Rolland |
| Abstract |
Baclofen a gamma amino-butyric acid type B (GABA-B) receptor agonist, which has raised some interest for the treatment of alcohol use disorder (AUD), occasionally at dose up to 300 mg/d. We conducted the first full-profile pharmacokinetic study on baclofen in AUD subjects, up to the oral daily dose of 300 mg. Sixty subjects treated for AUD with marketed baclofen were enrolled in a prospective phase-1 study. Participants were divided into four dose groups (1: <60 mg/d; 2: 60-120 mg/d; 3: >120 mg/d-180 mg/d; and 4: >180 mg/d), and they underwent a full-profile pharmacokinetic analysis of baclofen, using a nonlinear mixed effects modeling. The influence of different clinical and biological covariates was assessed in an upward modeling. Fifty-seven participants completed the study (522 observed concentrations collected). Racemic baclofen showed a linear pharmacokinetic profile, corresponding to a one-compartment model, with no influencing clinical or biological factor. The pharmacokinetic parameters of baclofen were (bootstrap 95% confidence intervals): absorption constant (Ka) 1.64 1/h (1.34-2), clearance (Cl/F) 11.6 L/h (10.8-12.3) and volume of distribution (Vd/F) 72.8 L (66.5-80.4) leading to a half-life of 4.4 h. The interindividual variability (IIV) was 44% (19-65), 21% (16-27), and 22% (11-36) for Ka, Cl/F, and Vd/F, respectively. The residual variability was 24% (21-26). No serious adverse event was reported. Registration: EudraCT #2013-003412-46. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 11 | 58% |
| Réunion | 1 | 5% |
| Switzerland | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 5 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 84% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 26% |
| Other | 3 | 13% |
| Researcher | 3 | 13% |
| Librarian | 1 | 4% |
| Lecturer | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 5 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 17% |
| Medicine and Dentistry | 4 | 17% |
| Psychology | 3 | 13% |
| Neuroscience | 2 | 9% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 6 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2018.
All research outputs
#2,264,363
of 23,098,660 outputs
Outputs from Frontiers in Psychiatry
#1,217
of 10,221 outputs
Outputs of similar age
#48,984
of 334,216 outputs
Outputs of similar age from Frontiers in Psychiatry
#36
of 176 outputs
Altmetric has tracked 23,098,660 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,221 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,216 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.