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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Age-Related Differences in Alcohol Intake and Control Over Alcohol Seeking in Rats
|
|---|---|
| Published in |
Frontiers in Psychiatry, September 2018
|
| DOI | 10.3389/fpsyt.2018.00419 |
| Pubmed ID | |
| Authors |
Maaike Labots, Janna Cousijn, Linda A. Jolink, J. Leon Kenemans, Louk J. M. J. Vanderschuren, Heidi M. B. Lesscher |
| Abstract |
Alcohol use disorder (AUD) is characterized by excessive and persistent alcohol use, despite adverse consequences. AUD often originates during adolescence, as do other substance use disorders. However, despite periods of excessive alcohol intake, many adolescents reduce their alcohol use by early adulthood. Brain development, social context, personality traits, and genetic makeup are thought to play an important role in these age-dependent fluctuations in alcohol use. However, studies that directly investigate age-related differences in the effects of alcohol exposure on brain and behavior are sparse. Therefore, to better understand the relationship between adolescent alcohol consumption and AUD-like behavior, this study compared the degree of control over alcohol seeking in rats that differed in terms of age of onset of alcohol drinking and in their level of alcohol consumption. We hypothesized that control over alcohol seeking is more prominent in adolescent-onset rats than in adult-onset rats, and that control over alcohol seeking is related to the consumed amount of alcohol. To test this hypothesis, alcohol seeking in the presence of a conditioned aversive stimulus was assessed after 2 months of intermittent alcohol access (IAA) in rats that consumed alcohol from postnatal day 42 (adolescence) or day 77 (adulthood). The rats were subdivided into low (LD), medium (MD), or high (HD) alcohol drinking rats, in order to assess the impact of the extent of alcohol intake on control over alcohol seeking. The adolescent-onset animals consumed slightly, but significantly less alcohol compared to the adult-onset rats. In adult-onset rats, we found that conditioned suppression of alcohol seeking, i.e., reduction of alcohol seeking by presentation of a conditioned aversive stimulus, was most pronounced in LD. By contrast, in the adolescent-onset rats, MD and HD showed increased alcohol seeking compared to LD, which was suppressed by conditioned aversive stimuli. Taken together, these findings reveal a complex relationship between the age of onset and level of alcohol intake with control over alcohol seeking, whereby adolescent rats consume less alcohol than adults. In adult rats, control over alcohol seeking is negatively related to preceding levels of alcohol intake. By contrast, adolescent rats appear to retain control over alcohol seeking, even after a history of high levels of alcohol intake. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 41% |
| Sweden | 1 | 5% |
| Netherlands | 1 | 5% |
| Spain | 1 | 5% |
| Switzerland | 1 | 5% |
| Unknown | 9 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 64% |
| Scientists | 6 | 27% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 14% |
| Student > Doctoral Student | 4 | 11% |
| Researcher | 3 | 8% |
| Student > Postgraduate | 2 | 6% |
| Student > Ph. D. Student | 2 | 6% |
| Other | 3 | 8% |
| Unknown | 17 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 8 | 22% |
| Neuroscience | 3 | 8% |
| Engineering | 2 | 6% |
| Agricultural and Biological Sciences | 2 | 6% |
| Medicine and Dentistry | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 17 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2018.
All research outputs
#2,696,778
of 24,995,564 outputs
Outputs from Frontiers in Psychiatry
#1,585
of 12,189 outputs
Outputs of similar age
#53,390
of 341,259 outputs
Outputs of similar age from Frontiers in Psychiatry
#39
of 190 outputs
Altmetric has tracked 24,995,564 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,189 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 190 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.