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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Stress, Cortisol and NR3C1 in At-Risk Individuals for Psychosis: A Mendelian Randomization Study
|
|---|---|
| Published in |
Frontiers in Psychiatry, July 2020
|
| DOI | 10.3389/fpsyt.2020.00680 |
| Pubmed ID | |
| Authors |
Anton Iftimovici, Oussama Kebir, Qin He, Thérèse M. Jay, ICAAR Study Group, Guy A. Rouleau, Marie-Odile Krebs, Boris Chaumette, Isabelle Amado, Julie Bourgin, Claire Daban Huard, Célia Jantac Mam-Lam-Fook, Marion Plaze, Fabrice Rivollier |
| Abstract |
The emergence of psychosis in at-risk individuals results from interactions between genetic vulnerability and environmental factors, possibly involving dysregulation of the hypothalamic-pituitary-adrenal axis. Hypercorticism was indeed described in schizophrenia and ultra-high-risk states, but its association with clinical outcome has yet to be demonstrated. The impact of stress through cortisol may vary depending on the expression level of genes related to the stress pathway. To test this hypothesis, we selected NR3C1, the gene encoding the glucocorticoid receptor, and modeled through logistic regression how its peripheral expression could explain some of the risk of psychosis, independently of peripheral cortisol levels, in a French longitudinal prospective cohort of 133 at-risk individuals, adjusted for sex, age, cannabis, and antipsychotic medication intake. We then performed a genome-wide association analysis, stratified by sex (55 females and 78 males), to identify NR3C1 expression quantitative trait loci to be used as instrumental variables in a Mendelian randomization framework. NR3C1 expression was significantly associated with a higher risk of conversion to psychosis (OR = 2.03, p = 0.03), independently of any other factor. Cortisol was not associated with outcome nor correlated with NR3C1. In the female subgroup, rs6849528 was associated both with NR3C1 mRNA levels (p = 0.015, Effect-Size = 2.7) and conversion (OR = 8.24, p = 0.03). For the same level of cortisol, NR3C1 expression increases psychotic risk, independently of sex, age, cannabis, and antipsychotic intake. In females, Mendelian randomization confirmed NR3C1's effect on outcome to be unbiased by any environmental confounder. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 5 | 29% |
| Switzerland | 2 | 12% |
| United States | 2 | 12% |
| United Kingdom | 1 | 6% |
| Slovenia | 1 | 6% |
| Canada | 1 | 6% |
| Unknown | 5 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 65% |
| Scientists | 4 | 24% |
| Practitioners (doctors, other healthcare professionals) | 2 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 18% |
| Student > Ph. D. Student | 5 | 10% |
| Student > Master | 3 | 6% |
| Researcher | 2 | 4% |
| Student > Postgraduate | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 24 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 14% |
| Psychology | 5 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Agricultural and Biological Sciences | 3 | 6% |
| Neuroscience | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 28 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2020.
All research outputs
#3,635,805
of 24,627,841 outputs
Outputs from Frontiers in Psychiatry
#2,144
of 11,878 outputs
Outputs of similar age
#89,902
of 402,086 outputs
Outputs of similar age from Frontiers in Psychiatry
#81
of 372 outputs
Altmetric has tracked 24,627,841 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,878 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 402,086 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 372 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.