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C-Reactive Protein Correlates with Negative Symptoms in Patients with Schizophrenia

Overview of attention for article published in Frontiers in Public Health, January 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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1 blog
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Citations

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31 Dimensions

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60 Mendeley
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Title
C-Reactive Protein Correlates with Negative Symptoms in Patients with Schizophrenia
Published in
Frontiers in Public Health, January 2018
DOI 10.3389/fpubh.2017.00360
Pubmed ID
Authors

Ted Boozalis, Antonio L. Teixeira, Raymond Young-Jin Cho, Olaoluwa Okusaga

Abstract

Peripheral and CNS-localized inflammatory processes are hypothesized to contribute to the complex pathophysiology of schizophrenia. Elevated levels of the acute phase reactant C-reactive protein (CRP) have been observed in schizophrenia, yet relatively few studies have investigated the association between this inflammatory biomarker and psychotic symptoms in schizophrenia. This study is a pilot cross-sectional analysis investigating the relation of plasma CRP levels and the positive and negative symptoms of schizophrenia (the primary aim), assessed by the Positive and Negative Syndrome Scale (PANSS). A secondary analysis was also performed evaluating the potential association of CRP with cognitive function using the NIH Toolbox Cognitive Test Battery. After adjusting for age, sex, race, and body mass index, a positive correlation was observed between CRP and PANSS negative symptoms (rho = 0.37, p = 0.05). There was no correlation between plasma CRP and any of the NIH Toolbox measures of cognitive function in the unadjusted or adjusted analyses. Though limited by a relatively small sample size and the unavailability of longitudinal data, the correlation between CRP and psychopathology in this sample of patients supports a role for inflammation in the pathophysiology of schizophrenia.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 13%
Researcher 8 13%
Student > Master 8 13%
Student > Bachelor 6 10%
Other 5 8%
Other 12 20%
Unknown 13 22%
Readers by discipline Count As %
Psychology 10 17%
Medicine and Dentistry 9 15%
Neuroscience 8 13%
Biochemistry, Genetics and Molecular Biology 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 8 13%
Unknown 17 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2018.
All research outputs
#3,777,768
of 23,018,998 outputs
Outputs from Frontiers in Public Health
#1,366
of 10,273 outputs
Outputs of similar age
#84,599
of 441,076 outputs
Outputs of similar age from Frontiers in Public Health
#36
of 107 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,273 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,076 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.