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The Role of Preradiosurgical Embolization in the Management of Grades III, IV, and V Arteriovenous Malformations

Overview of attention for article published in Frontiers in Surgery, June 2016
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Title
The Role of Preradiosurgical Embolization in the Management of Grades III, IV, and V Arteriovenous Malformations
Published in
Frontiers in Surgery, June 2016
DOI 10.3389/fsurg.2016.00037
Pubmed ID
Authors

Evandro C. Sousa, Manoel J. Teixeira, Ronnie L. Piske, Lavoisier S. Albuquerque, Sebastião Côrrea, Salomão Benabou, Leonardo C. Welling, Leonardo Moura de Sousa, Eberval Gadelha Figueiredo

Abstract

To evaluate the role of preradiosurgical embolization on obliteration rate, reduction of size, irradiation dose, and neurological outcome, in 90 patients presenting large arteriovenous malformations (AVMs). Between October 1993 and October 2006, 90 radiosurgical procedures were performed to treat brain AVMs Spetzler-Martin (SM) grades III, IV, and V at the Department of Radiosurgery and Radiology of the Real e Benemérita Associação Portuguesa de Beneficência de São Paulo, São Paulo, Brazil. Fifty-nine patients had embolization before radiosurgery and complete clinical and radiologic follow-up for at least 3 years. Inclusion criteria were as follow: SM grades III, IV, and V AVMs, no previous treatment, and clinical and radiological (angiogram and MRI) follow-up for at least 3 years. Obliteration rate, reduction of size, irradiation dose, and neurological outcome were compared in these two cohorts of patients. Mann-Whitney test, "Student's t-test," and χ(2) tests were used for statistical analysis, as appropriate. The level of significance was determined at p < 0.05. The mean size of the AVMs that underwent embolization was significantly greater when compared with non-embolized group (p < 0.05). Embolization significantly reduced the AVM diameter. Irradiation dose was significantly smaller in the embolized group (p < 0.05). No significant differences in final clinical outcomes, postprocedural radiological findings, rate of occlusion, and need for additional procedures were observed between the two groups (p < 0.05). Preradiosurgical embolization of large AVMs does not result in impaired obliteration rate compared with cases treated with radiosurgery alone. It did not add further morbidity and presented benefits of reducing size of the AVMs. Preradiosurgical embolization may facilitate the coverage of the AVM with the effective irradiation dose. Combined management may be effective for selected large lesions considered unsuitable for radiosurgery and otherwise untreatable.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 15%
Student > Doctoral Student 1 8%
Student > Bachelor 1 8%
Student > Master 1 8%
Researcher 1 8%
Other 2 15%
Unknown 5 38%
Readers by discipline Count As %
Medicine and Dentistry 7 54%
Neuroscience 1 8%
Chemical Engineering 1 8%
Unknown 4 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2016.
All research outputs
#18,464,797
of 22,879,161 outputs
Outputs from Frontiers in Surgery
#925
of 2,896 outputs
Outputs of similar age
#267,047
of 351,565 outputs
Outputs of similar age from Frontiers in Surgery
#14
of 19 outputs
Altmetric has tracked 22,879,161 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,896 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,565 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.