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MLVA and LPS Characteristics of Brucella canis Isolated from Humans and Dogs in Zhejiang, China

Overview of attention for article published in Frontiers in Veterinary Science, December 2017
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Title
MLVA and LPS Characteristics of Brucella canis Isolated from Humans and Dogs in Zhejiang, China
Published in
Frontiers in Veterinary Science, December 2017
DOI 10.3389/fvets.2017.00223
Pubmed ID
Authors

Dongri Piao, Heng Wang, Dongdong Di, Guozhong Tian, Jiantong Luo, Wenjie Gao, Hongyan Zhao, Weimin Xu, Weixing Fan, Hai Jiang

Abstract

Brucella canis is a pathogenic bacterium that causes brucellosis in dogs, and its zoonotic potential has been increasing in recent years. B. canis is a rare source of human brucellosis in China, where Brucella melitensis has been the major pathogen associated with human brucellosis outbreaks. In late 2011, a case of a B. canis infection was detected in a human patient in Zhejiang Province, China. To compare the genotypes between strains of B. canis isolated from the patient and from dogs, a multiple-locus variable-number tandem-repeat analysis (MLVA-16) was performed. In addition, the lipopolysaccharide-synthesis-related genes were analyzed with the B. canis reference strain RM6/66. 32 B. canis strains were divided into 26 genotypes using MLVA-16 [Hunter-Gaston Diversity Index (HGDI) = 0.976]. The HGDI indexes for various loci ranged between 0.000 and 0.865. All four Hangzhou isolates were indistinguishable using panel 1 (genotype 3) and panel 2A (genotype 28). However, these strains were distinctly different from other isolates from Beijing, Jiangsu, Liaoning, and Inner Mongolia at Bruce 09. The emergence of a human B. canis infection was limited to an area. Comparative analysis indicated B. canis from canines and humans have no differences in lipopolysaccharide-synthesis locus. The comprehensive approaches have been used to analyze human and canine B. canis isolates, including molecular epidemiological and LPS genetic characteristics. Further detailed analysis of the whole genomic sequencing will contribute to understanding of the pathogenicity of B. canis in humans.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 25%
Student > Ph. D. Student 2 10%
Researcher 2 10%
Student > Master 2 10%
Student > Postgraduate 2 10%
Other 3 15%
Unknown 4 20%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 6 30%
Agricultural and Biological Sciences 3 15%
Biochemistry, Genetics and Molecular Biology 2 10%
Medicine and Dentistry 2 10%
Social Sciences 1 5%
Other 1 5%
Unknown 5 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2017.
All research outputs
#17,923,510
of 23,012,811 outputs
Outputs from Frontiers in Veterinary Science
#3,508
of 6,320 outputs
Outputs of similar age
#308,165
of 439,953 outputs
Outputs of similar age from Frontiers in Veterinary Science
#43
of 68 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,320 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 439,953 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.