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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dynamic action of the Sec machinery during initiation, protein translocation and termination
|
|---|---|
| Published in |
eLife, June 2018
|
| DOI | 10.7554/elife.35112 |
| Pubmed ID | |
| Authors |
Tomas Fessl, Daniel Watkins, Peter Oatley, William John Allen, Robin Adam Corey, Jim Horne, Steve A Baldwin, Sheena E Radford, Ian Collinson, Roman Tuma |
| Abstract |
Protein translocation across cell membranes is a ubiquitous process required for protein secretion and membrane protein insertion. In bacteria, this is mostly mediated by the conserved SecYEG complex, driven through rounds of ATP hydrolysis by the cytoplasmic SecA, and the trans-membrane proton motive force. We have used single molecule techniques to explore SecY pore dynamics on multiple timescales in order to dissect the complex reaction pathway. The results show that SecA, both the signal sequence and mature components of the pre-protein, and ATP hydrolysis each have important and specific roles in channel unlocking, opening and priming for transport. After channel opening, translocation proceeds in two phases: a slow phase independent of substrate length, and a length-dependent transport phase with an intrinsic translocation rate of ~40 amino acids per second for the proOmpA substrate. Broad translocation rate distributions reflect the stochastic nature of polypeptide transport. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 12 | 46% |
| United States | 3 | 12% |
| China | 1 | 4% |
| Lebanon | 1 | 4% |
| Netherlands | 1 | 4% |
| Germany | 1 | 4% |
| Unknown | 7 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 50% |
| Scientists | 12 | 46% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 30% |
| Researcher | 8 | 13% |
| Student > Master | 8 | 13% |
| Student > Bachelor | 6 | 9% |
| Lecturer > Senior Lecturer | 3 | 5% |
| Other | 6 | 9% |
| Unknown | 14 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 45% |
| Agricultural and Biological Sciences | 10 | 16% |
| Chemistry | 4 | 6% |
| Immunology and Microbiology | 2 | 3% |
| Physics and Astronomy | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 16 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2021.
All research outputs
#2,360,007
of 24,003,070 outputs
Outputs from eLife
#6,614
of 14,668 outputs
Outputs of similar age
#49,582
of 333,009 outputs
Outputs of similar age from eLife
#165
of 344 outputs
Altmetric has tracked 24,003,070 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,668 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.0. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 344 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.