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X Demographics
Mendeley readers
Attention Score in Context
| Title |
β-Arrestin 2 Mediates G Protein-Coupled Receptor 43 Signals to Nuclear Factor-κB
|
|---|---|
| Published in |
Biological and Pharmaceutical Bulletin, August 2013
|
| DOI | 10.1248/bpb.b13-00312 |
| Pubmed ID | |
| Authors |
Su Ui Lee, Hyun Ju In, Mi So Kwon, Bi-oh Park, Minmi Jo, Mun-Ock Kim, Sungchan Cho, Sangku Lee, Hyun-Jun Lee, Young Shin Kwak, Sunhong Kim |
| Abstract |
G-protein coupled receptor 43 (GPR43) serves as a receptor for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 signaling remains unclear. Here, we show that β-arrestin 2 mediates the internalization of GPR43 by agonist. Agonism of GPR43 reduced the phosphorylation and nuclear translocation of nuclear factor-κB (NF-κB), which was relieved by short interfering RNA (siRNA) of β-arrestin 2. Subsequently, mRNA expression of proinflammatory cytokines, interleukin (IL)-6 and IL-1β, was downregulated by activation of GPR43 and knockdown of β-arrestin 2 recovered the expression of the cytokines. Taken together, these results suggest that GPR43 may be a plausible target for a variety of inflammatory diseases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 2 | 3% |
| Unknown | 71 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 19% |
| Student > Ph. D. Student | 11 | 15% |
| Student > Bachelor | 8 | 11% |
| Researcher | 6 | 8% |
| Student > Doctoral Student | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 20 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 12 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 11% |
| Immunology and Microbiology | 6 | 8% |
| Medicine and Dentistry | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 24 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2013.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Biological and Pharmaceutical Bulletin
#2,616
of 3,266 outputs
Outputs of similar age
#160,842
of 212,161 outputs
Outputs of similar age from Biological and Pharmaceutical Bulletin
#2
of 4 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,266 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,161 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.