Title |
β-Arrestin 2 Mediates G Protein-Coupled Receptor 43 Signals to Nuclear Factor-κB
|
---|---|
Published in |
Biological and Pharmaceutical Bulletin, August 2013
|
DOI | 10.1248/bpb.b13-00312 |
Pubmed ID | |
Authors |
Su Ui Lee, Hyun Ju In, Mi So Kwon, Bi-oh Park, Minmi Jo, Mun-Ock Kim, Sungchan Cho, Sangku Lee, Hyun-Jun Lee, Young Shin Kwak, Sunhong Kim |
Abstract |
G-protein coupled receptor 43 (GPR43) serves as a receptor for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 signaling remains unclear. Here, we show that β-arrestin 2 mediates the internalization of GPR43 by agonist. Agonism of GPR43 reduced the phosphorylation and nuclear translocation of nuclear factor-κB (NF-κB), which was relieved by short interfering RNA (siRNA) of β-arrestin 2. Subsequently, mRNA expression of proinflammatory cytokines, interleukin (IL)-6 and IL-1β, was downregulated by activation of GPR43 and knockdown of β-arrestin 2 recovered the expression of the cytokines. Taken together, these results suggest that GPR43 may be a plausible target for a variety of inflammatory diseases. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Argentina | 2 | 3% |
Unknown | 72 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 14 | 19% |
Student > Ph. D. Student | 12 | 16% |
Student > Bachelor | 8 | 11% |
Researcher | 6 | 8% |
Student > Doctoral Student | 3 | 4% |
Other | 10 | 14% |
Unknown | 21 | 28% |
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Other | 6 | 8% |
Unknown | 25 | 34% |