Mohamed Abdel-Mohsen, Rui André Saraiva Raposo, Xutao Deng, Manqing Li, Teri Liegler, Elizabeth Sinclair, Mohamed S Salama, Hussam El-din A Ghanem, Rebecca Hoh, Joseph K Wong, Michael David, Douglas F Nixon, Steven G Deeks, Satish K Pillai
Abstract
Several host-encoded antiviral factors suppress HIV-1 replication in a cell-autonomous fashion in vitro. The relevance of these defenses to the control of HIV-1 in vivo remains to be elucidated. We hypothesized that cellular restriction of HIV-1 replication plays a significant role in the observed suppression of HIV-1 in "elite controllers", individuals who maintain undetectable levels of viremia in the absence of antiretroviral therapy (ART). We comprehensively compared the expression levels of 34 host restriction factors and cellular activation levels in CD4+ T cells and sorted T cell subsets between elite controllers, HIV-1-infected (untreated) non-controllers, ART-suppressed, and uninfected individuals.
Pharmacology, Toxicology and Pharmaceutical Science
2
1%
Other
4
3%
Unknown
15
11%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2013.
All research outputs
#14,762,521
of 22,727,570 outputs
Outputs from Retrovirology
#733
of 1,104 outputs
Outputs of similar age
#124,880
of 210,723 outputs
Outputs of similar age from Retrovirology
#26
of 47 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,104 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,723 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
