Title |
Expression profile of host restriction factors in HIV-1 elite controllers
|
---|---|
Published in |
Retrovirology, October 2013
|
DOI | 10.1186/1742-4690-10-106 |
Pubmed ID | |
Authors |
Mohamed Abdel-Mohsen, Rui André Saraiva Raposo, Xutao Deng, Manqing Li, Teri Liegler, Elizabeth Sinclair, Mohamed S Salama, Hussam El-din A Ghanem, Rebecca Hoh, Joseph K Wong, Michael David, Douglas F Nixon, Steven G Deeks, Satish K Pillai |
Abstract |
Several host-encoded antiviral factors suppress HIV-1 replication in a cell-autonomous fashion in vitro. The relevance of these defenses to the control of HIV-1 in vivo remains to be elucidated. We hypothesized that cellular restriction of HIV-1 replication plays a significant role in the observed suppression of HIV-1 in "elite controllers", individuals who maintain undetectable levels of viremia in the absence of antiretroviral therapy (ART). We comprehensively compared the expression levels of 34 host restriction factors and cellular activation levels in CD4+ T cells and sorted T cell subsets between elite controllers, HIV-1-infected (untreated) non-controllers, ART-suppressed, and uninfected individuals. |
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