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Nitro-fatty acids: novel anti-inflammatory lipid mediators

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, September 2013
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Title
Nitro-fatty acids: novel anti-inflammatory lipid mediators
Published in
Brazilian Journal of Medical and Biological Research, September 2013
DOI 10.1590/1414-431x20133202
Pubmed ID
Authors

H. Rubbo

Abstract

Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 15%
Student > Master 10 15%
Student > Ph. D. Student 9 14%
Student > Bachelor 5 8%
Student > Postgraduate 4 6%
Other 13 20%
Unknown 15 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 26%
Agricultural and Biological Sciences 10 15%
Chemistry 8 12%
Nursing and Health Professions 4 6%
Immunology and Microbiology 2 3%
Other 7 11%
Unknown 18 27%