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Serotonin transporter gene polymorphisms: a case-control study

Overview of attention for article published in Brazilian Dental Journal, March 2012
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Title
Serotonin transporter gene polymorphisms: a case-control study
Published in
Brazilian Dental Journal, March 2012
DOI 10.1590/s0103-64402012000100012
Pubmed ID
Authors

Evandro Neves Abdo, Jeane de Fátima Correia-Silva, Carolina Cavaliéri Gomes, Isabela Almeida Pordeus, Ricardo Santiago Gomez

Abstract

Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). As alcohol and tobacco consumption have been implicated in the pathogenesis of oral cancer, the purpose of this study was to investigate 5-HTTLPR polymorphism in patients with oral squamous cell carcinoma (OSCC) compared with a control group in a sample of Brazilian patients. One hundred and three patients affected by OSCC and 103 volunteers without OSCC were genotyped for 5-HTTLPR. Both groups were matched for age, sex and tobacco use. The chi-squared test was used for statistical analysis (α=0.05). There was no statistically significant difference in 5-HTTLPR genotypes between case and control group (p= 0.408). In conclusion, the present investigation demonstrated that serotonin transporter polymorphisms are not implicated in the OSSC development.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 32%
Student > Postgraduate 5 16%
Student > Doctoral Student 4 13%
Student > Master 2 6%
Student > Ph. D. Student 2 6%
Other 5 16%
Unknown 3 10%
Readers by discipline Count As %
Medicine and Dentistry 12 39%
Biochemistry, Genetics and Molecular Biology 3 10%
Agricultural and Biological Sciences 3 10%
Psychology 2 6%
Nursing and Health Professions 1 3%
Other 3 10%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2012.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Brazilian Dental Journal
#108
of 284 outputs
Outputs of similar age
#112,628
of 172,587 outputs
Outputs of similar age from Brazilian Dental Journal
#4
of 6 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 284 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,587 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.