Title |
Serotonin transporter gene polymorphisms: a case-control study
|
---|---|
Published in |
Brazilian Dental Journal, March 2012
|
DOI | 10.1590/s0103-64402012000100012 |
Pubmed ID | |
Authors |
Evandro Neves Abdo, Jeane de Fátima Correia-Silva, Carolina Cavaliéri Gomes, Isabela Almeida Pordeus, Ricardo Santiago Gomez |
Abstract |
Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). As alcohol and tobacco consumption have been implicated in the pathogenesis of oral cancer, the purpose of this study was to investigate 5-HTTLPR polymorphism in patients with oral squamous cell carcinoma (OSCC) compared with a control group in a sample of Brazilian patients. One hundred and three patients affected by OSCC and 103 volunteers without OSCC were genotyped for 5-HTTLPR. Both groups were matched for age, sex and tobacco use. The chi-squared test was used for statistical analysis (α=0.05). There was no statistically significant difference in 5-HTTLPR genotypes between case and control group (p= 0.408). In conclusion, the present investigation demonstrated that serotonin transporter polymorphisms are not implicated in the OSSC development. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 3% |
Unknown | 30 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 32% |
Student > Postgraduate | 5 | 16% |
Student > Doctoral Student | 4 | 13% |
Student > Master | 2 | 6% |
Student > Ph. D. Student | 2 | 6% |
Other | 5 | 16% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 39% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Agricultural and Biological Sciences | 3 | 10% |
Psychology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |