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Frontiers | APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics ➡️https://t.co/LIQzGjEMjR
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5/16 🧵 APOE interacts with cholesterol and lipids in the plasma membrane and CNS, helping to maintain/repair components of the brain, and clear β-amyloid protein. The ε4 allele of this gene 🟰 ⬆️ AD risk while the ε2 allele 🟰 a protective effect. 🛑 https
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Kidneys. "Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity" https://t.co/ZDTo2aEIe2 https://t.co/C2Y3t1gnKO