Title |
Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis
|
---|---|
Published in |
Frontiers in immunology, February 2021
|
DOI | 10.3389/fimmu.2021.606384 |
Pubmed ID | |
Authors |
Zhuoyue Li, Kayleen J. McCafferty, Robert L. Judd |
Abstract |
Hydroxycarboxylic acid receptor 2 (HCA2) is vital for sensing intermediates of metabolism, including β-hydroxybutyrate and butyrate. It also regulates profound anti-inflammatory effects in various tissues, indicating that HCA2 may serve as an essential therapeutic target for mediating inflammation-associated diseases. Butyrate and niacin, endogenous and exogenous ligands of HCA2, have been reported to play an essential role in maintaining intestinal homeostasis. HCA2, predominantly expressed in diverse immune cells, is also present in intestinal epithelial cells (IECs), where it regulates the intricate communication network between diet, microbiota, and immune cells. This review summarizes the physiological role of HCA2 in intestinal homeostasis and its pathological role in intestinal inflammation and cancer. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 93% |
Unknown | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Researcher | 2 | 7% |
Student > Ph. D. Student | 2 | 7% |
Other | 4 | 13% |
Unknown | 13 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 23% |
Medicine and Dentistry | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Arts and Humanities | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Other | 1 | 3% |
Unknown | 13 | 43% |