Title |
Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs
|
---|---|
Published in |
Frontiers in Behavioral Neuroscience, January 2011
|
DOI | 10.3389/fnbeh.2011.00076 |
Pubmed ID | |
Authors |
Emanuela Santini, Eric Klann |
Abstract |
In the last decade, a plethora of studies utilizing pharmacological, biochemical, and genetic approaches have shown that precise translational control is required for long-lasting synaptic plasticity and the formation of long-term memory. Moreover, more recent studies indicate that alterations in translational control are a common pathophysiological feature of human neurological disorders, including developmental disorders, neuropsychiatric disorders, and neurodegenerative diseases. Finally, translational control mechanisms are susceptible to modification by psychoactive drugs. Taken together, these findings point to a central role for translational control in the regulation of synaptic function and behavior. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | 14% |
Central African Republic | 1 | 14% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Mexico | 1 | 1% |
Unknown | 72 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 22% |
Researcher | 15 | 20% |
Student > Master | 10 | 14% |
Student > Doctoral Student | 7 | 9% |
Student > Bachelor | 6 | 8% |
Other | 10 | 14% |
Unknown | 10 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 30% |
Neuroscience | 12 | 16% |
Medicine and Dentistry | 11 | 15% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Psychology | 4 | 5% |
Other | 4 | 5% |
Unknown | 14 | 19% |