Title |
Untangling the Manganese-α-Synuclein Web
|
---|---|
Published in |
Frontiers in Neuroscience, August 2016
|
DOI | 10.3389/fnins.2016.00364 |
Pubmed ID | |
Authors |
Tanara Vieira Peres, Nancy L. Parmalee, Ebany J. Martinez-Finley, Michael Aschner |
Abstract |
Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and α-synuclein (α-Syn) aggregation. The role of the α-Syn protein vis-a-vis Mn is controversial, as it seemingly plays a duplicitous role in neuroprotection and neurodegeneration. α-Syn has low affinity for Mn, however an indirect interaction cannot be ruled out. In this review we will examine the current knowledge surrounding the interaction of α-Syn and Mn in neurodegenerative process. |
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