Title |
An update on antibody-based immunotherapies for Clostridium difficile infection
|
---|---|
Published in |
Clinical and Experimental Gastroenterology, August 2016
|
DOI | 10.2147/ceg.s84017 |
Pubmed ID | |
Authors |
Greg Hussack, Jamshid Tanha |
Abstract |
Clostridium difficile continues to be one of the most prevalent hospital-acquired bacterial infections in the developed world, despite the recent introduction of a novel and effective antibiotic agent (fidaxomicin). Alternative approaches under investigation to combat the anaerobic Gram-positive bacteria include fecal transplantation therapy, vaccines, and antibody-based immunotherapies. In this review, we catalog the recent advances in antibody-based approaches under development and in the clinic for the treatment of C. difficile infection. By and large, inhibitory antibodies that recognize the primary C. difficile virulence factors, toxin A and toxin B, are the most popular passive immunotherapies under investigation. We provide a detailed summary of the toxin epitopes recognized by various antitoxin antibodies and discuss general trends on toxin inhibition efficacy. In addition, antibodies to other C. difficile targets, such as surface-layer proteins, binary toxin, motility factors, and adherence and colonization factors, are introduced in this review. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 13% |
Researcher | 7 | 13% |
Student > Master | 5 | 9% |
Student > Bachelor | 4 | 7% |
Other | 4 | 7% |
Other | 9 | 17% |
Unknown | 18 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 22% |
Medicine and Dentistry | 6 | 11% |
Immunology and Microbiology | 5 | 9% |
Agricultural and Biological Sciences | 5 | 9% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 6 | 11% |
Unknown | 19 | 35% |