HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations

@andrewpcone @naninizhoni @CaesarSalad99 For example, it took us a very long time to understand that HIV enters a "latency period." Upon first emergence, people seemed to clear HIV to non-detectable levels in the blood. But what was happening was that it s

“It is conceivable that naturally occurring mutations in Tat may modulate transactivation or other Tat functions, and that consequently affect the establishment and reversal of HIV-1 latency in vivo.” https://t.co/2qK75iFTCx