1/2) Complex I¹ produces ⏬mtROS at IF (FMN °site) & IQ (Q binding °) and thru ⏬RET [backward electron transfer from *QH2 to NAD+]. https://t.co/GFzScOvfca Fig.1C When CoQ (ubiquinone) pool becomes over-reduced, a ↑Δψm favors RET from *ubiquinol to ¹.
1/2) Complex I¹ ⏬ produces mtROS at IF (FMN °site) & IQ (Q binding °) and thru 🔽RET [backward electron transfer from *QH2 to NAD+]. https://t.co/GFzScOvfca Fig.1C When CoQ (ubiquinone) pool becomes over-reduced, a ↑Δψm favors RET from *ubiquinol to ¹.
2/2) During RET, electrons leak at either IF or IQ⤴️ → ↑superoxide (O2·-) RET has been shown to help Mφ activation ‘in response to’ bacterial infec, ETC re-organization ‘ ’ “changes in” energy supply & carotid body adaptation to “ ” O2 levels. 👉 https
mt dysfunction° Precedes podocyte fusion & proteinuria in an aldosterone-infused 🐭 model.^ Can lead to epithelial-to-mesenchymal transition 🔽 of renal tubular epithelial cells, contributing to fibrogenic process. https://t.co/GFzScOvfca ^Fig.10‥ https