Margaretha Dramsdahl, Lars Ersland, Kerstin J. Plessen, Jan Haavik, Kenneth Hugdahl, Karsten Specht
Abstract
Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex in adults with ADHD and healthy controls. Methods: Twenty-nine adults with ADHD and 38 healthy controls were included. We used Proton Magnetic Resonance Imaging with single voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre) in the left and the right midfrontal region in the two groups. Results: The ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls. Conclusion: The reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD, resulting in problems with cognitive control.
Pharmacology, Toxicology and Pharmaceutical Science
2
3%
Other
8
13%
Unknown
13
22%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2012.
All research outputs
#21,885,607
of 24,417,958 outputs
Outputs from Frontiers in Psychiatry
#8,895
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Outputs of similar age
#178,378
of 188,641 outputs
Outputs of similar age from Frontiers in Psychiatry
#33
of 37 outputs
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