Citrullination of myelin has been implicated in autoimmune response and remyelination failure. Cit. requires both PAD and Ca2+ as a cofactor. Ca2+ might be provided by its indiscriminate influx through non-synaptic NMDAr (likely displaced by HERV-w). 👀 ht
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New article: Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology https://t.co/SbMPqBBp7M #MS #multiplesclerosis #neurology https://t.co/2lNGWZcXu7
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RT @FrontImmunol: New Research: Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pa…
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RT @FrontImmunol: New Research: Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pa…