Title |
Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain
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Published in |
Frontiers in Genetics, January 2012
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DOI | 10.3389/fgene.2012.00273 |
Pubmed ID | |
Authors |
José A. G. Agúndez, Francisco Abad-Santos, Ana Aldea, Hortensia Alonso-Navarro, María L. Bernal, Alberto M. Borobia, Emma Borrás, Miguel Carballo, Alfonso Carvajal, José D. García-Muñiz, Guillermo Gervasini, Félix J. Jiménez-Jiménez, María I. Lucena, Carmen Martínez, José A. Sacristán, Inés Salado, Blanca Sinués, Jorge Vicente, Elena García-Martín |
Abstract |
The development of clinical practice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance with regard to adverse drug reactions. The potential of pharmacogenomic biomarkers has been extensively investigated in recent years. However, several barriers to implementing the use of pharmacogenomics testing exist. We conducted a survey among members of the Spanish Societies of Pharmacology and Clinical Pharmacology to obtain information about the perception of such barriers and to compare the perceptions of participants about the relative importance of major gene/drug pairs. Of 11 potential barriers, the highest importance was attributed to lack of institutional support for pharmacogenomics testing, and to the issues related to the lack of guidelines. Of the proposed gene/drug pairs the highest importance was assigned to HLA-B/abacavir, UGT1A1/irinotecan, and CYP2D6/tamoxifen. In this perspective article, we compare the relative importance of 29 gene/drug pairs in the Spanish study with that of the same pairs in the American Society for Clinical Pharmacology and Therapeutics study, and we provide suggestions and areas of focus to develop a guide for clinical practice in pharmacogenomics testing. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 17% |
Student > Ph. D. Student | 4 | 13% |
Student > Master | 3 | 10% |
Other | 2 | 7% |
Professor | 2 | 7% |
Other | 4 | 13% |
Unknown | 10 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Agricultural and Biological Sciences | 3 | 10% |
Economics, Econometrics and Finance | 1 | 3% |
Other | 1 | 3% |
Unknown | 9 | 30% |