The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury

RT @drgautammehta: @ebtapper Ugo Soffientini showed this last year: https://t.co/qtT5cfYxo1 Treat a healthy mouse with 'moderate' dose LP…

@ebtapper Ugo Soffientini showed this last year: https://t.co/qtT5cfYxo1 Treat a healthy mouse with 'moderate' dose LPS, and they recover well. Cirrhotic mice, treated with even low-dose LPS, develop liver cell death and multi-organ injury. Sensitized t

@uclnews @UCLInfectImm @RoyalFreeNHS @RajivJalan1 #Pyroptosis is a pro-inflammatory mode of cell death, important in response to PAMPs. #Cirrhosis patients have upregulated #pyroptosis signalling in the liver so are predisposed to poor Covid-19 outcomes (S

New Research: The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury: Background and Aims The development of multi-organ injury in cirrhosis is associated… https://t.co/g