Insulin activates urate transport in human kidney cell lines and oocytes. Mainly via activation of urate reuptake by SLC2A9 (aka GLUT9). Signaling via the Akt / Mapk pathway. https://t.co/Pg3ZomM394
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@ALGaffoRheumMD @HenryZelada2 @G_CANgout @UABRheum Thanks Angelo. Yes, that would be the assumption. Changing BMI changes insulin sensitivity and influences urate levels via an influence on urate excretion. See David Mount's recent paper https://t.co/xGbQ1
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The latest publication from Otago Biochemistry Genetic and Physiological Effects of Insulin on Human Urate Homeostasis https://t.co/kl9qOaEY6x Front Physiol. 2021 Aug 2;12:713710. doi: 10.3389/fphys.2021.713710. eCollection 2021. ABSTRACT Insulin and… h
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RT @FrontPhysiol: New Research: Genetic and Physiological Effects of Insulin on Human Urate Homeostasis https://t.co/dZFIrzLSVg #Physiology