“In one cluster (n = 15), patients [had] … low antigenic levels of MBL, C4, C3, Factor B, and C5 compared to all the other clusters; this cluster had the higher proportion of patients who died (27%) and required oxygen support (80%) or ICU care (53%).” ht
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intriguing information https://t.co/gf1lKPxo9A
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C3 cleavage can also be initiated in the absence of antibodies, via so-called alternative and lectin pathways. These pathways are hyper-activated in SCV2-induced ARDS; in nonsevere cases the classical (antibody) pathway dominates. https://t.co/8xcdFvmAJe