The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems https://t.co/1C25jGymmt
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Our new mini-review on #SARM1 and its striking mechanistic similarities to bacterial phage defense and toxin-antitoxin systems
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SARM1 TIR NADase:Defense,Toxin-Antitoxin:Toll/IL-1R(TIR)domain is signat signal motif of innate immunity,canonically funct as scaffolds,stim-depend multimerizatn gen bindg site for signal molec(kinase/ligase)activ downstream immunity.TIR domain metab NAD+
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RT @FrontImmunol: New Research: The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems: The…