Title |
Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells
|
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Published in |
Frontiers in Physiology, January 2013
|
DOI | 10.3389/fphys.2012.00483 |
Pubmed ID | |
Authors |
Bing-Chen Liu, Xiao-Yu Lu, Xiang Song, Ke-Yu Lei, Abdel A. Alli, Hui-Fang Bao, Douglas C. Eaton, He-Ping Ma |
Abstract |
Scanning ion-conductance microscope (SICM), which enables high-resolution imaging of cell surface topography, has been developed for over two decades. However, only recently, a unique scanning mode is increasingly used in biological studies to allow SICM to detect the surface of live cells. More recently, in combination with confocal microscopy and patch-clamp electrophysiological techniques, SICM allows investigators to localize proteins or ion channels in a specific nanostructure at the cell surface. This article will briefly review SICM nanotechnique and summarize the role of SICM in biological studies. |
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