PAPER OF THE WEEK Urban et al. studied gain-of-function mutations in the C2 protein @FrontImmunol. Mutant proteins resulted in higher complement-dependent cytotoxicity of antibody-sensitized cells, higher C3 deposition on CRP & endothelial cells. Read
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Another great paper on complement genetics in @FrontImmunol: https://t.co/UidmIT6lL5 Gain-of-function mutations in C2, found in patients with a glomerulopathy of uncertain etiology, were functionally characterized. Mutant proteins increased C3 deposition
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RT @FrontImmunol: New Research: Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence…
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New Research: Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein: The impairment of the alternative complement pathway contributes to rare kidney diseases such as… https://t.co/q