Francisco Purroy, Enric Sánchez, Albert Lecube, Gloria Arqué, Mikel Vicente-Pascual, Gerard Mauri-Capdevila, Núria Torreguitart, Marta Hernández, Ferrán Barbé, Elvira Fernández, Reinald Pamplona, Cristina Farràs, Dídac Mauricio, Marcelino Bermúdez-López, the ILERVAS project, José Manuel Valdivielso, Serafí Cambray, Eva Castro, Montserrat Martínez-Alonso, Manuel Portero-otín, Mariona Jové, Ferran Rius, Jessica González, Silvia Barril, Gerard Torres, Pere Godoy, Eva Miquel, Marta Ortega, Esmeralda Castelblanco, Josep Franch-Nadal
Abstract
Background: Little is known about the prevalence of cerebral microangiopathy (CM), which is related to cognitive impairment, in an asymptomatic population. Pulsatility index (PI) is an easily measurable parameter of cerebral vascular resistance in transcranial duplex of the middle cerebral artery (MCA) study. We aimed to determine the prevalence of CM measured by PI of MCA in low to moderate vascular risk subjects. Methods: We included 3,721 subjects between 45 and 70 years without previous history of vascular disease or diabetes mellitus and with at least one other vascular risk factor from the cross-sectional study ILERVAS (Lleida, Spain). Patients underwent transcranial duplex to determine MCA-PI. Possible CM was defined by MCA-PI >1.1. Carotid and femoral arteries ultrasound registration was done to determine the presence, the number, and the area of atheromatous plaques. Body mass index (BMI), pulse pressure (PP) and laboratory data were also recorded. Results: 439 (11.8%) subjects were excluded due to the low quality of transcranial duplex images. Median age was 57 [IQR 52, 62] years. Possible CM was found in 424 (12.9%) subjects. CM patients had higher prevalence of plaques than non-CM (77.4 vs. 66.4%, p < 0.001). PI showed a positive linear correlation with the number of territories with plaques (r = 0.130, p < 0.001), and the total plaque area (r = 0.082, p < 0.001). The predictors of possible CM were the age, male gender, and PP. Conclusions: In low-to-moderate vascular risk asymptomatic population, the proportion of abnormal brain microvascular bed determined by MCA-PI is not negligible. The planned 10-year follow-up will describe the clinical relevance of these findings.
Pharmacology, Toxicology and Pharmaceutical Science
1
7%
Nursing and Health Professions
1
7%
Other
1
7%
Unknown
6
43%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2022.
All research outputs
#18,504,575
of 22,925,760 outputs
Outputs from Frontiers in Neurology
#7,801
of 11,832 outputs
Outputs of similar age
#359,388
of 501,717 outputs
Outputs of similar age from Frontiers in Neurology
#334
of 668 outputs
Altmetric has tracked 22,925,760 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,832 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 501,717 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 668 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
