Title |
MicroRNA dysregulation in multiple sclerosis
|
---|---|
Published in |
Frontiers in Genetics, January 2013
|
DOI | 10.3389/fgene.2012.00311 |
Pubmed ID | |
Authors |
Omar de Faria, Craig S. Moore, Timothy E. Kennedy, Jack P. Antel, Amit Bar-Or, Ajit S. Dhaunchak |
Abstract |
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) demyelination and axonal degeneration. Although the cause of MS is still unknown, it is widely accepted that novel drug targets need to focus on both decreasing inflammation and promoting CNS repair. In MS and experimental autoimmune encephalomyelitis, non-coding small microRNAs (miRNAs) are dysregulated in the immune system and CNS. Since individual miRNAs are able to down-regulate multiple targeted mRNA transcripts, even minor changes in miRNA expression may lead to significant alterations in gene expression. Herein, we review miRNA signatures reported in CNS tissue and immune cells of MS patients and consider how altered miRNA expression may influence MS pathology. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 131 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 30 | 23% |
Student > Ph. D. Student | 29 | 22% |
Student > Master | 21 | 16% |
Student > Bachelor | 12 | 9% |
Student > Doctoral Student | 7 | 5% |
Other | 20 | 15% |
Unknown | 14 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 36 | 27% |
Biochemistry, Genetics and Molecular Biology | 26 | 20% |
Medicine and Dentistry | 24 | 18% |
Neuroscience | 15 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 7 | 5% |
Unknown | 21 | 16% |