Title |
T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities
|
---|---|
Published in |
Frontiers in immunology, September 2016
|
DOI | 10.3389/fimmu.2016.00353 |
Pubmed ID | |
Authors |
Zhan Wang, Binghao Li, Yingqing Ren, Zhaoming Ye |
Abstract |
Even though combining surgery with chemotherapy has significantly improved the prognosis of osteosarcoma patients, advanced, metastatic, or recurrent osteosarcomas are often non-responsive to chemotherapy, making development of novel efficient therapeutic methods an urgent need. Adoptive immunotherapy has the potential to be a useful non-surgical modality for treatment of osteosarcoma. Recently, alternative strategies, including immunotherapies using naturally occurring or genetically modified T cells, have been found to hold promise in the treatment of hematologic malignancies and solid tumors. In this review, we will discuss possible T-cell-based therapies against osteosarcoma with a special emphasis on combination strategies to improve the effectiveness of adoptive T cell transfer and, thus, to provide a rationale for the clinical development of immunotherapies. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | 13% |
Unknown | 7 | 88% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
France | 1 | 1% |
Unknown | 73 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 16% |
Student > Ph. D. Student | 11 | 15% |
Researcher | 9 | 12% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 4 | 5% |
Other | 12 | 16% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 23% |
Biochemistry, Genetics and Molecular Biology | 16 | 21% |
Immunology and Microbiology | 5 | 7% |
Agricultural and Biological Sciences | 4 | 5% |
Engineering | 3 | 4% |
Other | 6 | 8% |
Unknown | 24 | 32% |