Title |
The effects of amlodipine and platelet rich plasma on bone healing in rats
|
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Published in |
Drug Design, Development and Therapy, April 2015
|
DOI | 10.2147/dddt.s80778 |
Pubmed ID | |
Authors |
Yusuf Atalay, Mehmet Fatih Bozkurt, Yucel Gonul, Omer Cakmak, Kamil Serkan Agacayak, Ibrahim Köse, Omer Hazman, Hikmet Keles, Ozan Turamanlar, Mehmet Eroglu |
Abstract |
The aim of this study was to evaluate the effects of calcium channel blocker (CCB) amlodipine (AML), platelet rich plasma (PRP), and a mixture of both materials on bone healing. Fifty-six male Wistar rats were randomly divided into four groups: group A, tibia defect model with no treatment; group B, tibia defect model treated with AML, 0.04 mg daily by oral gavage; group C, tibia defect model treated with local PRP; group D, tibia defect model treated with local PRP and AML, 0.04 mg daily by oral gavage. At day 21, bone healing was significantly better in groups C and D compared to group A (P<0.05), but comparisons showed no statistically significant difference in group B (P>0.05). At day 30, groups B and C showed no statistically significant difference (P>0.05) compared to group A, but bone healing in group D was significantly better than in group A (P<0.05). Statistically, AML did not affect alkaline phosphatase (ALP) activity at 21 and 30 days (P>0.05), but PRP and AML + PRP increased ALP activity statistically (P<0.05). It can be concluded that AML had neither a positive nor a negative effect on bone healing, but when used in combination with PRP, it may be beneficial. |
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