Title |
GSK-3 and mitochondria in cancer cells
|
---|---|
Published in |
Frontiers in oncology, January 2013
|
DOI | 10.3389/fonc.2013.00016 |
Pubmed ID | |
Authors |
Federica Chiara, Andrea Rasola |
Abstract |
GSK-3 is a multifunctional kinase that is located in the cytosol, nucleus, and mitochondria of all cell types, and it is involved in the pathogenesis of a variety of diseases. In cancer, GSK-3 modulates the response of the cell death machinery to stress stimuli, including chemotherapeutics. Mitochondria are at the heart of the integration between survival and noxious signals; therefore, modulation of the mitochondrial functions carried out by GSK-3 is profoundly involved in the apoptosis escape capabilities that hallmark neoplasms. This review briefly covers the mechanistic interactions among oncogenic kinase pathways, GSK-3 activity and subsequent modulation of mitochondrial functions that shape the pro-survival phenotype of cancer cells, such as control of redox homeostasis and inhibition of the mitochondrial permeability transition pore. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Mexico | 1 | 1% |
Russia | 1 | 1% |
Spain | 1 | 1% |
Japan | 1 | 1% |
Unknown | 62 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 18% |
Student > Ph. D. Student | 9 | 13% |
Student > Master | 9 | 13% |
Professor > Associate Professor | 6 | 9% |
Student > Doctoral Student | 5 | 7% |
Other | 12 | 18% |
Unknown | 14 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 31% |
Biochemistry, Genetics and Molecular Biology | 11 | 16% |
Medicine and Dentistry | 10 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Neuroscience | 2 | 3% |
Other | 5 | 7% |
Unknown | 16 | 24% |