Title |
Liver Fibrogenesis in Non-Alcoholic Steatohepatitis
|
---|---|
Published in |
Frontiers in Physiology, January 2012
|
DOI | 10.3389/fphys.2012.00248 |
Pubmed ID | |
Authors |
Zhaolian Bian, Xiong Ma |
Abstract |
Non-alcoholic fatty liver disease (NAFLD) is emerging as one of the most common chronic liver diseases in developed western countries. Non-alcoholic steatohepatitis (NASH) is the most severe form of NAFLD, and can progress to more severe forms of liver disease, including fibrosis, cirrhosis, and even hepatocellular carcinoma. The activation of hepatic stellate cells plays a critical role in NASH-related fibrogenesis. Multiple factors, such as insulin resistance, oxidative stress, pro-inflammatory cytokines and adipokines, and innate immune responses, are known to contribute to the development of NASH-related fibrogenesis. Furthermore, these factors may share synergistic interactions, which could contribute to the process of liver fibrosis. Given the complex etiology of NASH, combined treatment regimes that target these different factors provide potential treatment strategies for NASH-related liver fibrosis. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Venezuela, Bolivarian Republic of | 1 | 50% |
Spain | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 22% |
Researcher | 5 | 12% |
Student > Bachelor | 4 | 10% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 6 | 15% |
Unknown | 10 | 24% |
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Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Environmental Science | 1 | 2% |
Other | 5 | 12% |
Unknown | 11 | 27% |