Title |
Identification of Cell Surface Antigen Expression in Canine Hepatocellular Carcinoma Cell Lines
|
---|---|
Published in |
Journal of Veterinary Medical Science, February 2013
|
DOI | 10.1292/jvms.12-0549 |
Pubmed ID | |
Authors |
Ayumi FUJIMOTO, Sakurako NEO, Chinatsu ISHIZUKA, Takashi KATO, Kazuhito SEGAWA, Shinpei KAWARAI, Kikumi OGIHARA, Masaharu HISASUE, Ryo TSUCHIYA |
Abstract |
The characteristics of surface antigens in canine hepatocellular carcinoma (cHCC) have not been clarified. The objective of this study was to investigate surface antigens, which are considered as stem/progenitor or cancer cell markers, in cHCC cell lines. Expression of various antigens including CD29, CD34, CD44, CD90, CD133 and Dlk-1 was assessed in four cHCC cell lines by flow cytometry. CD44, CD133 and Dlk-1 expression was detectable in all cell lines, and three cell lines expressed CD29. These results indicate that CD29, CD44, CD133 and Dlk-1 have potential as suitable markers in cHCC identification, suggesting that these findings will contribute to the establishment of an early diagnostic tool for the identification of hepatocellular maturation processes. |
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