Title |
The smallest unit: effector and memory CD8+ T cell differentiation on the single cell level
|
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Published in |
Frontiers in immunology, January 2013
|
DOI | 10.3389/fimmu.2013.00031 |
Pubmed ID | |
Authors |
Veit R. Buchholz, Patricia Gräf, Dirk H. Busch |
Abstract |
CD8(+) T cell immune responses provide immediate protection against primary infection and durable memory capable of rapidly fighting off re-infection. Immediate protection and lasting memory are implemented by phenotypically and functionally distinct T cell subsets. While it is now widely accepted that these diverge from a common source of naïve T cells (T(n)), the developmental relation and succession of effector and memory T cell subsets is still under intense debate. Recently, a distinct memory T cell subset has been suggested to possess stem cell-like features, sparking the hope to harness its capacity for self-renewal and diversification for successful therapy of chronic infections or malignant diseases. In this review we highlight current developmental models of memory generation, T cell subset diversification and T cell stemness. We discuss the importance of single cell monitoring techniques for adequately mapping these developmental processes and take a brief look at signaling components active in the putative stem cell-like memory T cell compartment. |
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