https://t.co/qcmkJaQ4zI "#STAT3 binds upstream of the Akt1 translation start site, and the interaction of Stat-3 with the corresponding region can increase Akt1 gene transcription." #AKT
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3,946 followers
https://t.co/qcmkJaQ4zI "Dyslipidemia can lead to excessive FFAs in plasma, thereby weakening PI3K/Akt pathway conduction, increasing reactive oxygen species (ROSs), and increasing endothelin-1 (ET-1) production, which together lead to endothelial dysfunc
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https://t.co/qcmkJaQ4zI "Visceral obesity leads to endothelial dysfunction through the effects of resistin, interleukin (IL)-6, and tumor necrosis factor α (TNF-α) on eNOS phosphorylation."
3,946 followers
https://t.co/qcmkJaQ4zI "Since the hemodynamic effects of insulin require phosphorylation of eNOS, endothelial dysfunction reduces blood flow to skeletal muscles, thus forming a vicious circle in which endothelial dysfunction worsens IR."