Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor

https://t.co/mUMeu9C7HW "Thus, the knockout of the Asic1a gene in mice protected the brain from ischemic injury, implicating ASIC1a as the main executor of acidotoxicity."

https://t.co/mUMeu9C7HW "Among them, the ASIC1a isoform forms proton-activated cation channels that account largely for the acidosis-induced neuronal injury in the cerebrum."

https://t.co/mUMeu9C7HW "In the central nervous system, acid-sensing ion channels (ASICs) are the main receptors that detect the acidosis signal."

Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor https://t.co/mUMeu9C7HW