RT @FrontPartners: On #NationalFentanylAwarenessDay, learn how fentanyl overdose is impacted by the lipid membrane: "Interaction With the L…
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On #NationalFentanylAwarenessDay, learn how fentanyl overdose is impacted by the lipid membrane: "Interaction With the Lipid Membrane Influences Fentanyl Pharmacology" by Sutcliffe et al. Published by ADAR, official journal of IDARS and @INRCmeeting ⏬ h
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@evolutionarypsy Found that paper on fent, it does posit higher lipophilicity along with longer molecular structure as cause of slowed kinetics v most other OPμr agonists https://t.co/HSLRH1Z85u
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Thinking this could be another piece in the puzzle of xylazine side effects: Some fent gets absorbed *intact* into fat cells and is released slowly. On release, perhaps normal response to vasoconstriction gets modulated. So then when xylazine withdrawal h