Title |
New Triterpene Aldehydes, Lucialdehydes A—C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells
|
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Published in |
Chemical and Pharmaceutical Bulletin, January 2002
|
DOI | 10.1248/cpb.50.837 |
Pubmed ID | |
Authors |
Jiang-Jing Gao, Byung-Sun Min, Eun-Mi Ahn, Norio Nakamura, Hyeong-Kyu Lee, Masao Hattori |
Abstract |
Three new lanostante-type triterpene aldehydes, named lucialdehydes A-C (1-3), were isolated from the fruiting bodies of Ganoderma lucidum, together with ganodermanonol (4), ganodermadiol (5), ganodermanondiol (6), ganodermanontriol (7), ganoderic acid A (8), ganoderic acid B8 (9), and ganoderic acid C1 (10). The structures of the new triterpenes were determined as (24E)-3 beta-hydroxy-5 alpha-lanosta-7,9(11),24-trien-26-al (1), (24E)-3,7-dioxo-5 alpha-lanosta-8,24-dien-26-al (2), and (24E)-3 beta-hydroxy-7-oxo-5 alpha-lanosta-8,24-dien-26-al (3), respectively, by spectroscopic means. The cytotoxicity of the compounds isolated from the ganoderma mushroom was tested in vitro against Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines. Lucialdehydes B, C (2, 3), ganodermanonol (4) and ganodermanondiol (6) showed cytotoxic effects on tested tumor cells. Of the compounds, lucialdehyde C (3) exhibited the most potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED(50) values of 10.7, 4.7, 7.1, and 3.8 microg/ml, respectively. |
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Geographical breakdown
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Japan | 1 | 1% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 13% |
Student > Bachelor | 8 | 12% |
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Unknown | 12 | 17% |
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Biochemistry, Genetics and Molecular Biology | 5 | 7% |
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