Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV

Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcγRIIA — In presence of PF4, human anti-PF4/P IgG and platelets, E. coli killing (> 50%) with colony forming units (CFU mL−1) 0.71×104 observed vs control https:

Platelet Levels vs 28-Day Mortality in Sepsis (Large Clinical Database MIMIC-IV) — 28-day septic mortality nearly 2X in platelet very low vs low group (HR=2.24; 1.92–2.6) — Death fell by 13% for every 10×10^9/L growth in platelets (when count <100×10^9/